KMID : 0438520110180010124
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Journal of the Korean Society of Neonatology 2011 Volume.18 No. 1 p.124 ~ p.129
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Oral Sildenafil in Persistent Pulmonary Hypertension of the Newborn
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Son Su-bin
Kim Kyung-Ah Youn So-Young Ko Sun-Young Lee Yeon-Kyung Shin Son-Moon
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Abstract
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Purpose: To evaluate the effect of oral sildenafil therapy in neonates with persistent pulmonary hypertension of the newborn (PPHN)
Methods: We conducted a retrospective review of 32 neonates ¡Ã35 weeks¡¯ gestation and fraction of inspired oxygen (FiO2) 1.0 with PPHN. The first dose (0.5 mg/kg) of oral sildenafil was started and 1 mg/kg was given every 6 hour thereafter. Mean airway pressure (MAP), FiO2, oxygenation index (OI), mean arterial blood pressure (MBP) were documented before and 6, 12, 24, and 48 hours after sildenafil. For adverse effects, gastrointestinal symptoms, brain ultrasound, funduscopy and auditory brainstem response results were evaluated.
Results: The underlying diseases of PPHN (n=32) were meconium aspiration syndrome (n=9), respiratory distress syndrome (n=8), pneumonia (n=3), and idiopathic (n=12). Thirty-one neonates survived; 3 neonates were transferred for inhaled nitric oxide (iNO) and all of them survived. In 28 infants, FiO2 and OI improved significantly by 6 hours and MAP improved significantly by 48 hours after initiation of sildenafil. There were no clinically significant adverse effects of sildenafil.
Conclusion: Sildenafil may be an effective and safe agent for near-term and term neonates with PPHN, providing significant improvement in oxygenation, and thus may be especially useful in the treatment of PPHN in hospitals without iNO.
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KEYWORD
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Sildenafil, Persistent pulmonary hypertension of the newborn
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